ORIGINAL ARTICLE
Year : 2013  |  Volume : 23  |  Issue : 1  |  Page : 6-8

Epstein-Barr virus association with malignant lymphoma subgroups in Zaria, Nigeria


1 Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
2 Department of Pathology, Ohio State University, Columbus, Ohio, USA

Correspondence Address:
Yawale Iliyasu
Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1116-5898.127096

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Epstein-Barr virus (EBV) is said to infect more than 90% of humans worldwide with latent infection for life. A recognized carcinogen, EBV is linked to malignant lymphoma (ML) subtypes of Burkitt's lymphoma, plasmablastic lymphoma, diffuse large cell lymphoma and Hodgkin's lymphoma. We report the association of EBV with ML in a segment of our patient population. Paraffin blocks from the archives of Ahmadu Bello University Teaching Hospital Zaria were used to construct tissue microarray. Sections were stained using 30 monoclonal antibodies for common non-Hodgkin's lymphoma/Hodgkin's lymphoma antigen. Chromogenic in situ hybridization for EBV-encoded RNA was done. Fewer associations of ML with EBV (54-5%) were found than reported elsewhere in Africa.


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